It appears that periodontal disease is a collection of illnesses with overlapping symptomatology rather than a single illness with varying clinical signs. Periodontal diseases may have a complex character. Given that many risk factors for periodontal disease tend to cluster in families for genetic or cultural reasons, it will be crucial to take these factors into account when researching familial clustering or potential genetic causes. Finding potential genes that could be the cause of a person's genetic vulnerability to periodontal disease will be crucial. The most obvious candidate genes are those that may influence how the immune system reacts to oral bacteria, but further study of disease-predisposing features, such as those related to tissue response, may reveal new hints regarding potential candidate genes. Clinical professionals may be better equipped to identify high-risk individuals for specialized prevention and treatment if these genes are discovered. The majority of the time, the existence of a number of environmental risk factors combined with a number of susceptibility variables during a specific stage of life is what most often leads to periodontitis developing in a person. The stronger the genetic predisposition and the greater the risk for early periodontitis development, the more susceptibility factors a person has inherited. As our understanding of the genes responsible for both major and modifiable diseases grows, numerous genetic tests may be developed. Medline, the Cochrane Database of Systematic Reviews, and DARE were used to compile the database. The database was compiled over the last 25 years, taking into account all developments and new evidence that occurred during that time. Running a preliminary search and noting the terms used in the titles and abstracts as well as the subject headers helped make the search more sensitive. The key concept was kept in mind, and synonym terms were searched using MeSH headings. By adhering to the inclusion and exclusion criteria for selecting articles, search results were narrowed down to those that supplied information and support for both periodontitis and genetics. The only articles left out were those that covered genetics in general.