Analysis Protein Drugs Design Program with Quality and Structure Prediction
DOI:
https://doi.org/10.31033/abjar.2.2.1Keywords:
development, design, proteinAbstract
A complete lack of hair will result when the "hairless protein" associated with the hairless gene, which is required for hair growth, ceases to function. The coordinates of this gene are 22027873-22045326 on chromosome 8. The JmjC domain superfamily includes the hairless gene, which also contributes to the process of histone demethylation. The domain sequence is 212 amino acids long and spans residue positions 946 to 1157 in the hairless protein, which has 1189 residues. JmjC domains have been discovered in more than 100 eukaryotic and bacterial sequences based on considerable sequence similarity, including the human hairless gene, which is mutated in people with alopecia universalis. To homology model the JmjC domain in the hairless protein, we have tried the bioinformatics method. NCBI-BLASTP, EBIClustalW, SMART, 3D-PSSM, DeepView/Swiss-PDB Viewer, PyMOL, and WhatCheck are the tools and programs utilized in this work. Using the template crystal structure of the likely antibiotic production protein from Thermus thermophilus HB8, the structure of the JmjC domain is predicted. Modeled domain structure's minimized energy value was -3394.570 KJ/mol. The simulated domain structure was validated using the WHAT IF-Proteins Model Check tool.
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