The Virulence of a Mouse-Adapted Semliki Forest Mechanism: a Model to Study the Pathogenesis

Authors

  • Abhimaan Tiwari Student, Department of Biology, Noorul Islam Centre for Higher Education, Thucklay, India
  • Dr. N. Tiwari Assistant Professor, Department of Biology, Noorul Islam Centre for Higher Education, Thucklay, India

DOI:

https://doi.org/10.31033/abjar.2.3.1

Keywords:

virulence, pathogenesis, semliki

Abstract

Vectors from the Semliki Forest virus (SFV) have been created to offer a simple method for expressing protein-encoding sequences in almost any animal cell. Acute encephalitis, subacute demyelinating meningoencephalomyelitis, and persistent subclinical central nervous system (CNS) infection are possible infection outcomes in mice, depending on age and viral strain. Infected mice under 12 days old exhibit severe symptoms of all viral types. While the A7 (74) strain is virulent, the L10 strain is equally pathogenic in mice older than 14 days.

Downloads

Download data is not yet available.

References

Aguilar, P. V., Paessler, S., Carrara, A. S., Baron, S., Poast, J., Wang, E., Moncayo, A. C., Anishchenko, M., Watts, D., & other authors (2005).Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus. J Virol, 79, 11300–11310.

Boyd, A., Fazakerley, J. K., & Bridgen, A. (2006). Pathogenesis of dugbe virus infection in wild-type and interferon-deficient mice. J Gen Virol, 87, 2005– 2009.

Bradish, C. J., Allner, K., & Maber, H. B. (1971). The virulence of original and derived strains of Semliki Forest virus for mice, guinea pig sand rabbits. J Gen Virol, 12, 141–160.

Cameron, K. R., & bradish, C. J. (I972). The kinetics of haemagglutination by Semliki Forest virus: a new sedimentation-enumeration method. Journal of General Virology, I6, I35-I52.

Deuber, S. A., & Pavlovic, J. (2007). Virulence of a mouse-adapted Semliki Forest virus strain is associated with reduced susceptibility to interferon. J Gen Virol, 88, 1952– 1959.

Dussaix, E., Lebon, P., Ponsot, G., Huault, G., & Tardieu, M. (1985). Intrathecal synthesis of different a-interferons in patients with various neurological diseases. Acta Neurol Scand, 71, 504– 509.

Fazakerley, J. K. (2004). Semliki Forest virus infection of laboratory mice: a model to study the pathogenesis of viral encephalitis. Arch Virol Suppl, 18, 179–190.

Grieder, F. B., & Vogel, S. N. (1999). Role of interferon and interferon regulatory factors in early protection against Venezuelan equine encephalitis virus infection. Virology, 257, 106–118.

Koerner, I., Kochs, G., Kalinke, U., Weiss, S., & Staeheli, P. (2007).Protective role of beta interferon in host defense against influenza Avirus. J Virol, 81, 2025–2030.

Published

2023-05-31

How to Cite

Abhimaan Tiwari, & Dr. N. Tiwari. (2023). The Virulence of a Mouse-Adapted Semliki Forest Mechanism: a Model to Study the Pathogenesis. Applied Science and Biotechnology Journal for Advanced Research, 2(3), 1–3. https://doi.org/10.31033/abjar.2.3.1

Issue

Section

Articles