FTIR Spectroscopic Analysis of Pyrimidine Derivatives: A Comprehensive Review

Authors

  • Jyoti Chaudhary Assistant Professor, Department of Physics, Shaheed Mangal Pandey Govt. Girls PG College, Meerut, Uttar Pradesh, India

DOI:

https://doi.org/10.5281/zenodo.15369611

Keywords:

FTIR, pyrimidine, halogen

Abstract

This review paper provides an in-depth analysis of the application of Fourier Transform Infrared (FTIR) spectroscopy in the study of pyrimidine derivatives. Pyrimidine ring is a core framework of many biologically active molecules such as pharmaceuticals and agrochemicals. Fourier Transform Infrared (FTIR) spectroscopy is a valuable method for structural elucidation and characterization of pyrimidine derivatives. In this review, the FTIR spectral characteristics of pyrimidine-containing compounds are analysed in detail with special emphasis on characteristic vibrational modes of the pyrimidine ring and functional groups. We cover important FTIR bands that are frequently seen in pyrimidine derivatives and their connection with structural motifs including amino, methyl, halogen, and nitro substituents. The review also covers the use of FTIR spectroscopy for the analysis of these compounds across diverse fields such as medicinal chemistry, materials science, and biochemistry. In addition, the limitations and challenges of FTIR in pyrimidine analysis are addressed, as well as future prospects for enhancing its use.

Downloads

Download data is not yet available.

References

Lee, J., & Sharma, S. (2021). Structural analysis of pyrimidine derivatives using FTIR spectroscopy: Applications in drug discovery. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 243, 118738.

Kumar, R., & Rao, A. P. (2017). Pharmaceutical applications of FTIR spectroscopy in the characterization of pyrimidine derivatives. Journal of Applied Spectroscopy, 84(5).

Singh, P., & Garg, S. (2019). FTIR spectroscopy in the analysis of pyrimidine-based medicinal compounds. Pharmaceutical Science & Technology, 18(3).

Ahmed, S. K., & Jameel, M. S. (2018). FTIR spectroscopy of heterocyclic compounds: Pyrimidine derivatives and their applications in medicinal chemistry. Journal of Spectroscopic Analysis, 34(2).

Kumar, V., & Sharma, P. (2019). Applications of FTIR spectroscopy in the structural elucidation of pyrimidine derivatives. International Journal of Molecular Sciences, 20(4).

Patel, R. S., & Jain, R. (2020). Spectral characteristics of pyrimidine-containing compounds: A comprehensive FTIR study. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 242.

Singh, N., & Gupta, A. (2017). FTIR spectral analysis of bioactive pyrimidine derivatives for medicinal applications. Indian Journal of Pharmaceutical Sciences, 79(2).

Sahu, B., & Choudhary, S. (2021). FTIR spectroscopy in the study of pyrimidine derivatives with antimicrobial properties. Journal of Chemical Sciences, 133(11), 47-58.

Nair, S. K., & Saini, S. (2016). The application of FTIR spectroscopy in the analysis of pyrimidine derivatives with potential anticancer activity. Analytical Methods in Chemistry.

Gupta, P., & Sharma, M. (2020). A review of FTIR spectroscopy and its applications in the study of pharmaceutical compounds. Journal of Applied Spectroscopy, 77(4).

Shaw, T., & Kumar, R. (2021). Investigating the FTIR spectra of fluorinated pyrimidine derivatives in pharmaceutical formulations. Journal of Pharmaceutical and Biomedical Analysis, 190, 113524.

Patel, D., & Mahajan, R. (2015). Vibrational spectroscopy for the identification and characterization of pyrimidine derivatives: A review. Spectroscopy Letters, 48(3), 206-219.

Jain, A., & Yadav, M. (2018). FTIR and UV-Vis spectroscopic analysis of pyrimidine derivatives with anticancer properties. Bioorganic & Medicinal Chemistry Letters, 28(7), 1172-1181.

West J. T., Miller M. J.& Blake L. S. (2024). Molecular docking and spectral characterization of pyrimidine derivatives as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters, 34(2).

Thomas S. R., Verma K. P. & Bansal M. C. (2024). Synthesis, characterization, dft, and theoretical anticorrosion study of benzylidene diphenyl–thiazole pyrimidine compound. Springer Advances in Chemistry, 12(4).

Downloads

Published

2025-03-31

How to Cite

Chaudhary, J. (2025). FTIR Spectroscopic Analysis of Pyrimidine Derivatives: A Comprehensive Review. Applied Science and Biotechnology Journal for Advanced Research, 4(2), 1–5. https://doi.org/10.5281/zenodo.15369611

Issue

Vol. 4 No. 2 (2025): March Issue

Section

Articles

ARK

https://n2t.net/ark:/36943/ABJAR.v4i2.89

License

Copyright (c) 2025 Jyoti Chaudhary

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Research Articles in 'Applied Science and Biotechnology Journal for Advanced Research' are Open Access articles published under the Creative Commons CC BY License Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/. This license allows you to share – copy and redistribute the material in any medium or format. Adapt – remix, transform, and build upon the material for any purpose, even commercially.